Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide
Combination of
Adapalene Retinoid
Benzoyl peroxide Disinfectant
Clinical data
Trade names Epiduo
Pregnancy cat.
Legal status
  • Prescription only
Routes Epicutaneous
CAS number  YesY
ATC code D10, D10

Adapalene/benzoyl peroxide is a prescription drug combination for the treatment of acne, marketed by Galderma under the trade name Epiduo.[1] Its trade name in Canada is TactuPump, where it was previously known as Tactuo.[2]

It consists of a combination of adapalene (0.1%) and benzoyl peroxide (2.5%) in a topical gel formulation.[1] This preparation does not create any bacterial resistance during long-term application as it does not contain an antibiotic.


Patients are advised to exercise caution in using Epiduo together with other skin products containing sulfur, resorcinol, or salicylic acid, or with medicated or abrasive dirts and cleansers.[3] Skin products with high levels of alcohol or astringents should also be avoided.[3] Using topical products with a strong drying effect in combination with Epiduo can increase irritation.[3]

Side effects

Commonly reported side effects include:[3]


Apply topically after gently washing the areas the product will be applied with a non-medicated soap. Apply a thin layer to the affected area. Avoid contact of the product with the eyes, lips, and mucous membranes.[4][5]

Over the first few weeks of application it's common to experience dryness, scaling and/or peeling. This is a result of your skin getting use to the medication by unclogging pores. To minimize this at the start, you may consider one of the following options for application over the first few weeks:

  • Apply thin layer to the skin each night for 20-30 minutes at a time and then wash off.
  • First apply moisturizer and then apply Epiduo/TactuPump immediately following
  • Apply every 2nd night for the first 2 weeks until your skin adjusts to the medication


Patients are advised to avoid exposure to sunlight and sunlamps, and use sunscreen when these cannot be avoided.[3]


  1. ^ a b "FDA OKs New Acne Gel Epiduo". Retrieved 2012-01-25. 
  2. ^
  3. ^ a b c d e "Full prescribing information" (PDF). Retrieved 2012-01-25. 
  4. ^ >PharmacisAnswers Acne Products Webpage Retrieved Feb 13, 2014
  5. ^ Epiduo (adapalene and benzoyl peroxide) gel package insert. Fort Worth, TX: Galderma Laboratories, L.P.; 2011 June

External links

  • Epiduo official website
  • Tactuo Official Website (Canada -