Potassium channel opener

Potassium channel opener

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

Some examples include:

  • Diazoxide[1] vasodilator used for hypertension, smooth muscle relaxing activity
  • Minoxidil[2] vasodilator used for hypertension, also used to treat hair loss
  • Nicorandil[3] vasodilator used to treat angina
  • Pinacidil[4]
  • Retigabine,[5][6] an anticonvulsant
  • Flupirtine, analgesic with muscle relaxant and anticonvulsant properties

See also


  1. ^ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). "Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener". Circulation 112 (9 Suppl): I219–23.  
  2. ^ Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle". J. Pharmacol. Exp. Ther. 304 (2): 833–40.  
  3. ^ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). "Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction". Biol. Pharm. Bull. 31 (11): 2079–82.  
  4. ^ Stojnic N, Gojkovic-Bukarica L, Peric M, et al. (June 2007). "Potassium channel opener pinacidil induces relaxation of the isolated human radial artery". J. Pharmacol. Sci. 104 (2): 122–9.  
  5. ^ Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells". European Journal of Pharmacology 336 (2–3): 243–9.  
  6. ^ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular Pharmacology 58 (2): 253–62.